Pigeonpea leaves. Chin Tradit Herb Drugs 1985;16:134-6. 17. Luo QF, Sun L, Si JY, Chen DH. Hypocholesterolemic effect of stilbenes containing extract-fraction from Cajanus cajan L. on diet-induced hypercholesterolemia in mice. Phytomedicine 2008;15:932-9. 18. Huang GY, Liao XZ, Liao HF, Deng SJ, Tan YH, Zhou JY. Studies on water-soluble extracts from Cajanus cajan leaf against hypoxic-ischemic brain harm. Tradit Chin Drug Res Clin Pharmacol 2006;17:172-4. 19. Kundu R, Dasgupta S, Biswas A, Bhattacharya A, Pal BC, Bandyopadhyay D, et al. Cajanus cajan Linn. (Leguminosae) prevents alcohol-induced rat liver harm and augments cytoprotective function. J. Ethnopharmacol 2008;118:440-7. 20. Duker-Eshun G, Jaroszewski JW, Asomaning WA, OppongBoachie F, Christensen SB.3-Isopropylpyridin-2(1H)-one In stock Antiplasmodial constituents of Cajanus cajan. Phytother Res 2004;18:128-30. 21. Zu YG, Fu YJ, Liu W, Hou CL, Kong Y. Simultaneous determination of 4 flavonoids in pigeonpea [Cajanus cajan (L.) Millsp.] leaves applying RP-LC-DAD. Chromatographia 2006;63:499-505. 22. Zheng YY, Yang J, Chen DH, Sun L. Effects in the stilbene extracts from Cajanus cajan L. on ovariectomy-induced bone loss in rats. Yao Xue Xue Bao 2007;42:562-5. 23. Siddhuraju P. Antioxidant activity of polyphenolic compounds extracted from defatted raw and dry heated Tamarindus indica seed coat. LWT Food Science and Technologies 2007;40:982-90. 24. Maiti R, Das UK, Ghosh D. Attenuation of Hyperglycemia and Hyperlipidemia in Streptozotocin-Induced Diabetic Rats by Aqueous Extract of Seed of Tamarindus indica. Biol Pharm Bull 2005;28:1172-6. 25. Martinello F, Soaresh SM, Franco JJ, Santos AC, Sugohara A, Garcia SB, et al.Nα,Nα-Bis(carboxymethyl)-L-lysine Chemscene Hypolipemic and antioxidant activities from Tamarindus indica pulp fruit extract in hypercholesterolemic hamsters.PMID:23916866 Meals Chem Toxicol 2006;44:810-8. 26. Dighe NS, Pattan SR, Nirmal SA, Kalkotwar RS, Gaware VM, Hole MB. Analgesic activity of Tamarindus indica. Res J Pharmacogn Phytochem 2009;1:69-71. 27. Luengthanaphol S, Mongkholkhajornsilp D, Douglas S, Douglas PL, Pengsopa L, Pongamphai S. Extraction of antioxidants fromPharmacognosy Research | April-June 2014 | Vol 6 | IssueCONCLUSIONSMethanolic extract of MCC and MTI were discovered to include appreciable levels total cost-free phenolics with promising antioxidant and antidiabetic properties. This scientific facts can serve as an important platform for the development of further safe and effective organic medicine. Elucidation of the molecular mechanisms involved and isolation in the bioactive molecules implicated may possibly assist the improvement of plant-derived potent drugs which can replace the clinically toxic. Therefore, further investigations have to be undertaken for complete identification and characterization of the molecules responsible for antioxidant and antidiabetic activities of MCC and MTI.
Bulky “Gatekeeper” Residue Changes the Cosubstrate Specificity of Aminoglycoside 2 -Phosphotransferase IIaMonolekha Bhattacharya,a Marta Toth,a Clyde A. Smith,b Sergei B. VakulenkoaDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, USAa; Stanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California, USAbThe aminoglycoside 2 -phosphotransferases APH(2 )-IIa and APH(two )-IVa can utilize ATP and GTP as cosubstrates, since each enzymes possess overlapping but discrete structural templates for ATP and GTP binding. APH(two )-IIIa uses GTP exclusively, simply because its ATP-binding template is blocked by a bulky ty.
