Ich binds to each human DHFR (h-DHFR) and mt-DHFR without the need of any
Ich binds to both human DHFR (h-DHFR) and mt-DHFR with no any important selectivity7,8. Such inhibitors contain 2,4-Diaminopteridin as the central core and are referred to as classical inhibitors. Nevertheless,…